王勉 副教授，博士,硕士生导师
E-mail:mianwang23@163.com
个人简介：
本科、硕士毕业于中国药科大学，博士毕业于广西大学（其间在美国哈佛大学医学院进行一年的博士课题研究），2011年在中科院上海药物所进修。主持1项国家自然科学基金项目和3项广西自然科学基金，参与国家自然科学基金项目、广西自然科学基金重点项目等多个项目。发表SCI论文三十多篇，申请国家发明专利2项，并已授权。
本课题组硕士毕业生的去向：
刘飞扬：复旦大学攻读博士；
王艳：东南大学攻读博士；
李振杰、唐霞、周文龙、柯伟伟：药明康德公司工作；
陈瑶瑶、汪哲旭、徐飞：康龙化成新药技术有限公司工作；
翟兰姣：深圳科兴药业有限公司工作。
教学和科研成果：
针对CDK4、VEGFR、PARP、METTL3等靶点筛选到高活性的抗肿瘤化合物，具有良好的成药性和转化潜力。构建了可无创、实时监测肝脏疾病的靶向荧光探针，这些靶向诊断探针具有一定的临床应用前景。合成了双靶脂质材料，并制备了载抗肿瘤药物的靶向脂质体，该脂质体具有优良的体内肝靶向性及抗肿瘤效果。
主持承担的主要科研项目：
1项国家自然科学基金项目
2项广西自然科学基金面上项目
1项广西自然科学基金青年项目
研究方向：
（1）抗肿瘤及抗衰老药物的筛选、作用机制研究及药物靶点确证
（2）抗肿瘤前药及药物递送系统
（3）重大疾病早期诊断探针的研究
（4）大健康相关产品的研发
指导的学生获奖：
代表性论文：
1) Feiyang Liu, Xueyan Zhu，Yan Wang, Qingyuan Yi, Chunxiao Pu, Yi Luo*, Jianyi Wang*, Mian Wang*，A Glycocluster strategy to develop dual-cascade targeting fluorescence probe detecting Fe3+ in hepatocyte mitochondria，Sensors Actuat. B-Chem. 2023，374，132840 (SCI一区，Top）
2) Yan Wang, Feiyang Liu, Qingyuan Yi, Mian Wang*, Jianyi Wang*，Design, synthesis and biological evaluation of novel dual-targeting fluorescent probes for detection of Fe3+ in the lysosomes of hepatocytes mediated by galactose-morpholine moieties, Talanta, 2022, 243，123362 (SCI一区)
3) Yan Wang, Feiyang Liu, Chunxiao Pu, Zhangfa Tong, Mian Wang*, Jianyi Wang*. Galactose-imidazole mediated dual-targeting fluorescent probe for detecting Fe3+ in the lysosomes of hepatocytes: Design, synthesis and evaluation. Biosensors and Bioelectronics, 2022, 204, 114083 (IF:10.618, SCI一区, Top)
4) Mian Wang, Zhenjie Li, Feiyang Liu, Qingyuan Yi, Chunxiao Pu, Yajie Li, Tingrong Luo, Jian Liang, and Jianyi Wang*, Development of Asialoglycoprotein-Mediated Hepatocyte-Targeting Antitumor Prodrugs Triggered by Glutathione. J. Med. Chem. 2021, 64, 14793−14808. (IF: 7.446, SCI一区，Top)
5) Yan Wang, Ruihua Ding, Zan Zhang, Cheng Zhong, Jianyi Wang*, Mian Wang*, Curcumin-Loaded Liposomes with the Hepatic and Lysosomal Dual-Targeted Effects for Therapy of Hepatocellular Carcinoma, Int. J. Pharmaceut., 2021, 602，120628 (IF:5.875, SCI二区，Top)
6) Xiao-Yan Qin, Fan-Tao Meng, Mian Wang, Shu-Jiang Tu*, Wen-Juan Hao, Jianyi Wang*, and Bo Jiang*, Gold-Catalyzed Skeletal Rearrangement of Alkenes: Regioselective Synthesis of Skeletally Diverse Tricyclic Heterocycles and Mechanistic Investigations, ACS Catal. 2021, 11, 6951−6959 (IF: 13.08, SCI一区，Top)
7) Yamin Zhang, Zhenjie Li, Haibo Ge, Xueyan Zhu, Zhuang Zhao, Zhong-quan Qi, Mian Wang*, Jianyi Wang*，Dual Hepatocyte-Targeting Fluorescent Probe with High Sensitivity to Tumorous pH: Precise Detection of Hepatocellular Carcinoma Cells，Sensors & Actuators: B. Chemical. 2019, 285, 584-589 ( SCI一区，Top）
8) Hui Zhang, Zhenjie Li, Mian Wang,* Tingrong Luo, Liang Yi and Jianyi Wang *, Novel Hepatocyte-Targeting Fluorescent Probes for Detection of Hypochlorous Acid: Synergistic Effect of Phosphate and Galactose, Sensors & Actuators: B. Chemical, 2019, 279, 102–110 (SCI一区，Top）
9) Heng Li#, Wen-Juan Hao#, Mian Wang#, Xue Qin, Shu-Jiang Tu*, Peng Zhou, Guigen Li, Jianyi Wang,* and Bo Jiang*，Catalytic Double [2+2] Cycloaddition Relay Enabled C-C Triple Bond Cleavage of Yne−Allenones, Organic Letters, 2018, 20, 4362-4366 (共同第一作者, SCI一区，Top）
10) Ziyue Xie, Zhengcheng Liang, Yunhou Huang, Kaichuang Shi, Ning Zang, Mian Wang*, Taoyuan Liang*, Wanxing Wei*. Discovery and biological evaluation of 2-((3-phenylisoxazol-5-yl) methoxy) benzamide derivatives as potent nucleocapsid inhibitors. Journal of Molecular Structure. 2023, 1272, 134103.
11) Honghui Liu, Yan Wang, Mingxia Lv, Yi Luo, Bu-Ming Liu, Yan Huang, Mian Wang*, Jianyi Wang*. Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation. Bioorganic Chemistry. 2020,105, 104370-104380.
12) Ruihua Ding, Zhenjie Li, Jianyi Wang*, Xueyan Zhu, Zhuang Zhao, Mian Wang*, Design and synthesis of galactose-biotin lipid materials for liposomes to promote the hepatoma cell-targeting effect, Journal of Pharmaceutical Sciences, 2019, 108, 3074-3081.
13) Zhengcheng Liang, Yunhou Huang, Huihua Li, Xiaoxiang Zhang, Kaichuang Shi, Ning Zang, Mian Wang*, Taoyuan Liang*, Wanxing Wei*. Synthesis and evaluation of 3-phenylisoxazoline derivatives as nonnucleoside hepatitis B virus inhibitors. Tetrahedron. 2023, 130, 133177.
14) Zhengcheng Liang, Yongqing Tan, Yunhou Huang, Taoyuan Liang*, Wanxing Wei*, Mian Wang*, Kaichuang Shi. Design and Synthesis of (3-Phenylisoxazol-5-yl)methanimine Derivatives as Hepatitis B Virus Inhibitors. Chem. Biodiversity. 2023, 20, e202201247.
15) Hongping Zhang，Xueyan Zhu，Mian Wang*，Bu-Ming Liu，Yan Huang，Jianyi Wang*，A theoretical study of Fe(PMe3)4-catalyzed anti-Markovnikov addition of aromatics to alkenes to provide linear alkylation products. Transition Metal Chemistry, 2019, 44, 545-553.
16) Liang Yi，Yan Wang，Tingrong Luo，Wei Hu，Mian Wang*，Jianyi Wang*，Design, synthesis and evaluation of a novel hepatocyte-targeting fluorescent probe to accurately detect H2S in mitochondria, Dyes and Pigments, 2019, 166, 460-466.
17) Wei Hu, Zhengjun Chen, Mian Wang, Tingrong Luo, Jianyi Wang*, Design, synthesis and evaluation of HepDirect fluorescence probes mediated by asialoglycoprotein receptor, Dyes and Pigments, 2018, 159, 471–478
18) Lujuan Liao, Zhenjie Li, Wei Hu, Yan Huang, Bu-min Liu, Lisheng Wang, Mian Wang*, Jianyi Wang*. Design, synthesis and evaluation of a novel fluorescent probe to accurately detect H2S in lysosomes. Tetrahedron Letters, 2018,59(27),2683-2687.
19) Feiyang Liu,Piaoping Tang, Ruihua Ding, Lujuan Liao, Lisheng Wang,Mian Wang*,Jianyi Wang*. A glycosylation strategy to develop a low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium. Dalton Trans., 2017,46,7515–7522.
20) Jianyi Wang, Qing Chen, Mian Wang*, Cheng Zhong. The opening/closure of the P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib. Phys. Chem. Chem. Phys., 2017,19,22444--22453.
21) Mian Wang, Marc Baaden, Zhiqun Liang*, Jianyi Wang*. A Cooperative Mechanism of Clotrimazoles in P450 revealed by the Dissociation Picture of Clotrimazole from P450. Journal of Chemical Information and Modeling, 2014,54,1218-1225.
22) Wenhao Sheng, Mian Wang, Matthias Lein, Linbin Jiang, Wanxing Wei, Jianyi Wang*. Mechanism of Copper(I)-Catalyzed Allylic Alkylation of Phosphorothioate Esters: Influence of the Leaving Group on α Regioselectivity. Chemistry: A European journal 2013,19,14126–14142. (co-first author)
23) Xuesong Wu, Mian Wang, Guangwu Zhang,Yan Zhao, Jianyi Wang and Haibo Ge. Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Cyclization of Hydrazones via sp3 C-H Functionalization. Chem. Sci., 2015,6,5882-5890.（SCI 一区，top）
24) Jingxi Wu, Mian Wang, Lisheng Wang, Jianyi Wang*, Linbin Jiang*. How the bicyclo[4.1.0] substrate isomerizes into 4, 5-dihydrobenzo[b]furan: the contribution from W(CO)5 and NEt3. The Journal of Organic Chemistry 2013,78,10812-10820.
25) Jingzhou Yang*, Yu Shrike Zhang*, Pengfei Lei, Xiaozhi Hu, Mian Wang, Haitao Liu, Xiulin Shen, Kun Li, Zhaohui Huang, Juntong Huang, Jie Ju, Yihe Hu*, and Ali Khademhosseini*. “Steel–Concrete” Inspired Biofunctional Layered Hybrid Cage for Spine Fusion and Segmental Bone Reconstruction. ACS Biomaterials Science & Engineering. 2017, 3,637-647.
26) Mian Wang, Hao Luo, Min Zhang, and Jianyi Wang. Why trans- or cis-Dimethyl Fumarate Addition to 2,5-Dimethylpyrrole Gives Exclusively trans-7-Azanorbornane. J. Phys. Chem. A, 2015,119,6563-73.
27) Mian Wang, Hao Luo, Lisheng Wang, Jianyi Wang. What factors cause the complete substrate-controlled selectivity in Rh2(Piv)4-catalyzed cycloadditions of 1,2,3-triazoles with isocyanates or isothiocyanates. J. Organomet. Chem. 2015,788,58-67.
28) Jianyi Wang*, Dinglong Cai, Min Zhang, Mian Wang*. The addition mechanism of TMSCN into N-acetylpyridinum to give 2-cyanoacetylpyridinum: the roles of TpW(NO)(PMe3) and DABCO. Journal of Organometallic Chemistry. 2013,724,117-128.
29) Mian Wang, Yun Du, Jianyi Wang, Xiaomin Luo, Hualiang Jiang, Naixia Zhang*, Yechun Xu*. Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin. Molecular Simulation 2012,38,1015–1021.
30) Mian Wang, Jipeng Yang, Jianyi Wang*, Xiaojuan Wang. Structural effects of L16Q, S20G, and L16Q-S20G mutations on hIAPP: a comparative molecular dynamics study. Chinese Journal of Chemistry 2012,30,241–248.
